Dihexa: How It Works, What It's Studied For & Safety
Dihexa is a small angiotensin IV-derived hexapeptide studied in preclinical models for hepatocyte growth factor (HGF) signaling and synaptogenesis in cognitive-aging research. Clinicians consider it for cognitive-aging and synaptogenesis research. It is not FDA-approved as a finished drug product and is dispensed by Wells Pharmacy Network only after a licensed clinician evaluates intake, history, and labs.
Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408
How does Dihexa work?
Dihexa is an orally bioavailable angiotensin IV analog studied as a positive modulator of the HGF/c-Met signaling axis. Preclinical work describes promotion of dendritic spine formation, synaptogenesis, and improved performance in rodent learning and memory tasks.
What is Dihexa studied for?
- Cognitive-aging and synaptogenesis research
- Preclinical Alzheimer's-disease models
- Adjunct in clinician-directed nootropic protocols (investigational)
How is Dihexa taken?
Compounded as oral capsules or sublingual troches in clinician-directed protocols. Not commercially available as a finished drug.
Is Dihexa FDA-approved? Is it safe?
Not FDA-approved for the prevention, treatment, or cure of any condition. Used inside research-informed, clinician-directed protocols only. Human safety, dosing, and long-term effects are not established. Because HGF signaling can theoretically promote tumor growth, clinicians may avoid use in patients with active or recent malignancy. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about Dihexa?
Preclinical work from the Washington State University group reported pro-cognitive effects in rodent models. No published controlled human trials.
Citations & further reading
Considering Dihexa as part of a protocol?
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