Niacinamide: How It Works, What It's Studied For & Safety
Niacinamide is the amide form of vitamin B3, used widely in topical skin protocols for barrier-support, sebum-control, and pigmentation effects. Clinicians consider it for skin-barrier support and irritation reduction. It is not FDA-approved as a finished drug product and is dispensed by Wells Pharmacy Network only after a licensed clinician evaluates intake, history, and labs.
Also known as: Nicotinamide, Vitamin B3
How does Niacinamide work?
Niacinamide is a precursor to NAD+/NADP+ and is studied topically for inhibition of melanosome transfer to keratinocytes, support of ceramide synthesis (skin-barrier), and modulation of sebum production.
What is Niacinamide studied for?
- Skin-barrier support and irritation reduction
- Hyperpigmentation adjunct (often combined with hydroquinone or azelaic acid)
- Acne and rosacea-adjacent inflammation research
How is Niacinamide taken?
Available OTC as a topical (typical 5–10%). Compounded combination preparations are dispensed for clinician-directed skin protocols.
Is Niacinamide FDA-approved? Is it safe?
Well-tolerated as a topical. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about Niacinamide?
Multiple controlled trials support topical niacinamide for pigmentation and barrier-support endpoints.
Citations & further reading
Considering Niacinamide as part of a protocol?
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