Clomiphene: How It Works, What It's Studied For & Safety
Clomiphene is a selective estrogen receptor modulator (SERM) FDA-approved for ovulation induction in women, used off-label for HPG-axis support in men. Clinicians consider it for ovulation induction in women with anovulatory infertility (FDA-approved). Compounded variants are dispensed by Wells Pharmacy Network only after a clinician evaluation.
Also known as: Clomid, Clomiphene Citrate
How does Clomiphene work?
Clomiphene is a mixture of two isomers (enclomiphene and zuclomiphene) that block estrogen-receptor feedback at the hypothalamus. The result is increased GnRH pulsatility and downstream LH/FSH release, which raises endogenous testosterone in men and stimulates ovulation in women.
What is Clomiphene studied for?
- Ovulation induction in women with anovulatory infertility (FDA-approved)
- Off-label endogenous testosterone support in men with secondary hypogonadism
- Fertility-preserving alternative to TRT in men planning conception
How is Clomiphene taken?
FDA-approved as a daily oral tablet (50 mg). Compounded preparations exist for the lower-dose protocols sometimes used in male HPG-axis support.
Is Clomiphene FDA-approved? Is it safe?
FDA-approved as a finished drug product when prescribed under its labeled indications. Compounded variants on this site are separate from the branded product and are dispensed only when a clinician determines a compounded preparation is appropriate. The zuclomiphene isomer has a long half-life and accumulates with repeated dosing - one reason clinicians often prefer pure enclomiphene for male protocols. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about Clomiphene?
Decades of OB use; off-label male HPG-axis use is supported by mid-sized retrospective and small prospective studies.
Citations & further reading
Considering Clomiphene as part of a protocol?
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