Flibanserin: How It Works, What It's Studied For & Safety
Flibanserin is a serotonin 5-HT1A agonist and 5-HT2A antagonist FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women. Clinicians consider it for hypoactive sexual desire disorder (HSDD) in premenopausal women (FDA-approved). Compounded variants are dispensed by Wells Pharmacy Network only after a clinician evaluation.
Also known as: Addyi
How does Flibanserin work?
Flibanserin is a centrally acting non-hormonal molecule. It is studied for shifting prefrontal-cortex serotonin and dopamine balance in a way thought to support sexual desire signaling. Effects emerge over weeks of daily dosing.
What is Flibanserin studied for?
- Hypoactive sexual desire disorder (HSDD) in premenopausal women (FDA-approved)
- Off-label HSDD in postmenopausal women in clinician-directed protocols
How is Flibanserin taken?
FDA-approved as a 100-mg oral tablet taken once daily at bedtime.
Is Flibanserin FDA-approved? Is it safe?
FDA-approved as a finished drug product when prescribed under its labeled indications. Compounded variants on this site are separate from the branded product and are dispensed only when a clinician determines a compounded preparation is appropriate. Boxed warning regarding hypotension and syncope when combined with alcohol or strong CYP3A4 inhibitors. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about Flibanserin?
BEGONIA, DAISY, and VIOLET trials supported the approval; effect size was modest.
Citations & further reading
Considering Flibanserin as part of a protocol?
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