Progesterone: How It Works, What It's Studied For & Safety
Progesterone is an endogenous steroid hormone produced primarily by the corpus luteum and placenta; FDA-approved (Prometrium) and compounded preparations are used in hormone-replacement protocols. Clinicians consider it for endometrial protection during estradiol replacement (FDA-approved). Compounded variants are dispensed by Wells Pharmacy Network only after a clinician evaluation.
Also known as: P4, Prometrium
How does Progesterone work?
Progesterone binds progesterone receptors in the uterus, breast, brain, and other tissues. In hormone-replacement therapy it counterbalances estradiol's proliferative effect on the endometrium and is studied for sleep and mood effects via GABA-A modulation by its allopregnanolone metabolite.
What is Progesterone studied for?
- Endometrial protection during estradiol replacement (FDA-approved)
- Secondary amenorrhea (FDA-approved)
- Sleep, mood, and perimenopausal-symptom research
How is Progesterone taken?
FDA-approved as oral micronized capsules (Prometrium) and vaginal preparations. Compounded subcutaneous pellets and customized creams are dispensed in clinician-directed protocols.
Is Progesterone FDA-approved? Is it safe?
FDA-approved as a finished drug product when prescribed under its labeled indications. Compounded variants on this site are separate from the branded product and are dispensed only when a clinician determines a compounded preparation is appropriate. Sedation and dizziness at oral doses are common, which is why bedtime dosing is preferred. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about Progesterone?
Decades of OB-GYN clinical research; modern HRT guidelines recommend micronized progesterone over older synthetic progestins where feasible.
Citations & further reading
Considering Progesterone as part of a protocol?
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