GLP-1 receptor agonists like semaglutide and tirzepatide are powerful weight-loss tools, but studies show lean mass can be lost along with fat. This article reviews the evidence and provides a muscle preservation plan using protein, resistance training, and supportive peptides or hormones.

Microdosing GLP-1s like semaglutide and tirzepatide is emerging as a trend, with claims of fewer side effects and steady appetite control. While the theory sounds appealing, human data on microdosing is limited, and risks may outweigh benefits without proper medical oversight.