Storage & Handling

• Store unopened lyophilized vials at room temperature

• After reconstitution: refrigerate at 36–46°F

• Use within 24 hours

• Single-use only; discard unused portion

• Maintain strict aseptic technique  
  
  

Patient Eligibility & Safety

• Review medical history, medications, allergies, and prior reactions

• Avoid or use with caution in:

• Active infection at injection site

• Uncontrolled autoimmune disease

• Active malignancy unless cleared

• Pregnancy or breastfeeding (unless explicitly approved)

• Obtain written informed consent including off-label disclosure

• Record baseline vitals (HR, BP optional for SQ initiation)  

Preparation

1. Reconstitution:

Reconstitute vial with 0.5-1mL sterile wateror sterile preferred normal saline

• Inject slowly down vial wall

• Gently swirl - do not shake

• Ensure full dissolution before withdrawal  

2. Syringe Preparation

• Use insulin syringe (29–31g, 0.3–1 mL)

• Withdraw prescribed volume

• Expel air bubbles carefully

Administration - Subcutaneous Injection

Injection Sites

• Abdomen (≥2 inches from umbilicus)

• Love handles / flank

• Upper outer thigh

• Rotate sites with each injection

Technique

1. Clean site with alcohol prep

2. Pinch subcutaneous tissue

3. Insert needle at 45–90° angle

4. Inject slowly over 5–10 seconds

5. Withdraw needle, apply light pressure

6. Do not massage aggressively

Adverse Event Management

Mild

• Local erythema, swelling, itching

• Cold compress, oral antihistamine if needed

• Rotate injection sites
  
  

Moderate

• Lightheadedness, flushing, nausea

• Hold dose, hydrate, reassess dosing frequency

Severe (Rare)

• Anaphylaxis, chest tightness, dyspnea

• Activate emergency protocol

• Administer epinephrine, oxygen, EMS per ACLS guidelines  

Regulatory Status

• Quantum SQ administration is off-label

• Intended for use only by licensed healthcare providers

• Providers must be trained in injectable therapies and adverse-event management

• Use within scope of state licensure and clinical practice guidelines