MOTS-c: How It Works, What It's Studied For & Safety
MOTS-c is a 16-amino-acid mitochondrial-derived peptide studied for its role in metabolic homeostasis, insulin sensitivity, and exercise capacity. Clinicians consider it for insulin sensitivity and metabolic-aging research. It is not FDA-approved as a finished drug product and is dispensed by Wells Pharmacy Network only after a licensed clinician evaluates intake, history, and labs.
Also known as: Mitochondrial open reading frame of the 12S rRNA-c
How does MOTS-c work?
MOTS-c is encoded within the mitochondrial 12S rRNA gene and is studied for activation of AMPK, modulation of glucose and fat metabolism, and skeletal-muscle exercise-response signaling.
What is MOTS-c studied for?
How is MOTS-c taken?
Compounded as a subcutaneous injection in clinician-directed cycles, often 2-3 times weekly.
Is MOTS-c FDA-approved? Is it safe?
Not FDA-approved for the prevention, treatment, or cure of any condition. Used inside research-informed, clinician-directed protocols only. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about MOTS-c?
A growing body of preclinical metabolic research; phase-1 work is in progress for related mitochondrial-axis compounds.
Citations & further reading
Considering MOTS-c as part of a protocol?
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