SS-31: How It Works, What It's Studied For & Safety
SS-31 is a mitochondrial-targeted peptide that binds cardiolipin on the inner mitochondrial membrane, studied for cellular-energy and cardiovascular research. Clinicians consider it for heart failure with preserved ejection fraction (HFpEF) - phase-3 trial program (PROGRESS). Not FDA-approved; dispensed by Wells Pharmacy Network only after a clinician evaluation.
Also known as: Elamipretide, MTP-131, Bendavia
How does SS-31 work?
SS-31 (elamipretide) is a small, cell-permeable peptide that selectively localizes to the inner mitochondrial membrane and binds cardiolipin. By stabilizing cristae structure and supporting electron-transport-chain efficiency, it is studied for restoring mitochondrial bioenergetics in stressed or aged tissues.
What is SS-31 studied for?
- Heart failure with preserved ejection fraction (HFpEF) - phase-3 trial program (PROGRESS)
- Primary mitochondrial myopathy
- Age-related skeletal-muscle and cardiovascular endurance research
How is SS-31 taken?
Compounded as a subcutaneous injection in clinician-directed cycles. The branded clinical-trial preparation is administered as a daily subcutaneous injection.
Is SS-31 FDA-approved? Is it safe?
Not FDA-approved for the prevention, treatment, or cure of any condition. Used inside research-informed, clinician-directed protocols only. (Investigational under sponsor IND for specific mitochondrial indications.) Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about SS-31?
Multiple sponsor-led clinical trials in cardiac and mitochondrial-disease populations; results have been mixed and an FDA approval has not yet been issued.
Citations & further reading
Considering SS-31 as part of a protocol?
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