Sildenafil: How It Works, What It's Studied For & Safety
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor FDA-approved for erectile dysfunction (Viagra) and pulmonary arterial hypertension (Revatio). Clinicians consider it for erectile dysfunction in men (FDA-approved). Branded products are FDA-approved under labeled indications; compounded variants are dispensed by Wells Pharmacy Network only after a licensed clinician evaluates intake, history, and labs.
Also known as: Viagra, Revatio
How does Sildenafil work?
Sildenafil selectively inhibits PDE5, the enzyme that breaks down cyclic GMP in vascular smooth muscle. With PDE5 inhibited, the nitric-oxide / cGMP relaxation signal in the corpus cavernosum is sustained, supporting penile blood-flow during sexual stimulation.
What is Sildenafil studied for?
- Erectile dysfunction in men (FDA-approved)
- Pulmonary arterial hypertension (FDA-approved as Revatio)
- On-demand sexual-health protocols, sometimes combined with PT-141 or oxytocin
How is Sildenafil taken?
FDA-approved as oral tablets (25, 50, 100 mg). Compounded combination preparations (e.g., with PT-141, oxytocin, tadalafil, or testosterone) exist for clinician-directed protocols.
Is Sildenafil FDA-approved? Is it safe?
FDA-approved as a finished drug product when prescribed under its labeled indications. Compounded variants on this site are separate from the branded product and are dispensed only when a clinician determines a compounded preparation is appropriate. Contraindicated with nitrates and most alpha-blockers; cardiovascular history must be reviewed before starting. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about Sildenafil?
Two decades of post-approval clinical experience; PDE5 inhibitor benefit-risk profile is well-characterized.
Citations & further reading
Considering Sildenafil as part of a protocol?
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