Tadalafil: How It Works, What It's Studied For & Safety
Tadalafil is a long-acting PDE5 inhibitor FDA-approved for erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Clinicians consider it for erectile dysfunction (FDA-approved on-demand and daily). Branded products are FDA-approved under labeled indications; compounded variants are dispensed by Wells Pharmacy Network only after a licensed clinician evaluates intake, history, and labs.
Also known as: Cialis, Adcirca
How does Tadalafil work?
Tadalafil selectively inhibits PDE5 with a notably long plasma half-life (~17.5 hours), supporting both on-demand and daily-dosing strategies for ED and BPH symptoms.
What is Tadalafil studied for?
- Erectile dysfunction (FDA-approved on-demand and daily)
- Benign prostatic hyperplasia symptoms (FDA-approved)
- Pulmonary arterial hypertension (FDA-approved as Adcirca)
- Combination on-demand sexual-health protocols
How is Tadalafil taken?
FDA-approved as oral tablets (2.5, 5, 10, 20 mg). Compounded sublingual troches and oral combinations with PT-141, oxytocin, or testosterone exist for clinician-directed protocols.
Is Tadalafil FDA-approved? Is it safe?
FDA-approved as a finished drug product when prescribed under its labeled indications. Compounded variants on this site are separate from the branded product and are dispensed only when a clinician determines a compounded preparation is appropriate. Contraindicated with nitrates; caution with alpha-blockers. Cardiovascular review required. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about Tadalafil?
Long-term post-approval clinical experience supports both on-demand and daily-dose use cases.
Citations & further reading
Considering Tadalafil as part of a protocol?
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