5-Amino-1MQ: How It Works, What It's Studied For & Safety
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), studied for its effect on NAD+ recycling, fat metabolism, and metabolic-aging signaling. Clinicians consider it for nAD+ recycling and mitochondrial-energy research. It is not FDA-approved as a finished drug product and is dispensed by Wells Pharmacy Network only after a licensed clinician evaluates intake, history, and labs.
Also known as: 5-Amino-1-Methylquinolinium, 1MQ
How does 5-Amino-1MQ work?
5-Amino-1MQ inhibits NNMT, an enzyme that consumes the NAD+ precursor nicotinamide via methylation. By sparing nicotinamide for the NAD+ salvage pathway, it is studied for higher tissue NAD+ availability, increased adipocyte energy expenditure, and a shift toward fat oxidation in preclinical models.
What is 5-Amino-1MQ studied for?
- NAD+ recycling and mitochondrial-energy research
- Adjunct in clinician-directed body-composition and metabolic protocols
- Preclinical fat-loss and insulin-sensitivity research
How is 5-Amino-1MQ taken?
Compounded as oral capsules in clinician-directed cycles. Not commonly available as an injection.
Is 5-Amino-1MQ FDA-approved? Is it safe?
Not FDA-approved for the prevention, treatment, or cure of any condition. Used inside research-informed, clinician-directed protocols only. Long-term human safety data is limited. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about 5-Amino-1MQ?
Preclinical mouse data shows reductions in adiposity and improvements in metabolic markers; controlled human-outcome trials have not yet been published.
Citations & further reading
Considering 5-Amino-1MQ as part of a protocol?
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