BAM15: How It Works, What It's Studied For & Safety
BAM15 is a mitochondrial protonophore (uncoupler) studied for mild dissipation of the inner-membrane proton gradient and modest increases in resting energy expenditure. Clinicians consider it for preclinical obesity and insulin-sensitivity research. It is not FDA-approved as a finished drug product and is dispensed by Wells Pharmacy Network only after a licensed clinician evaluates intake, history, and labs.
Also known as: (2-fluorophenyl){6-[(2-fluorophenyl)amino](1,2,5-oxadiazolo[3,4-e]pyrazin-5-yl)}amine
How does BAM15 work?
BAM15 transports protons across the inner mitochondrial membrane, partially uncoupling oxidative phosphorylation. The result in preclinical models is increased substrate oxidation and heat production without measurable hyperthermia or membrane-potential collapse - distinguishing it from older, more toxic uncouplers like DNP.
What is BAM15 studied for?
- Preclinical obesity and insulin-sensitivity research
- Mitochondrial-bioenergetics research
- Adjunct in clinician-directed metabolic protocols (off-label, investigational)
How is BAM15 taken?
Compounded oral preparations in clinician-directed protocols. Not FDA-approved and not commercially available as a finished drug product.
Is BAM15 FDA-approved? Is it safe?
Not FDA-approved for the prevention, treatment, or cure of any condition. Used inside research-informed, clinician-directed protocols only. Mitochondrial uncouplers can theoretically increase resting heart rate and core temperature; clinician monitoring is appropriate. Human safety and dosing are not established. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about BAM15?
Mouse studies show reduced fat mass and improved insulin sensitivity without hyperthermia. No published controlled human trials.
Citations & further reading
Considering BAM15 as part of a protocol?
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