FOXO4-DRI: How It Works, What It's Studied For & Safety
FOXO4-DRI is a D-amino-acid retro-inverso peptide designed in 2017 to disrupt the interaction between FOXO4 and p53 in senescent cells. Clinicians consider it for senolytic research - selective clearance of senescent cells. Not FDA-approved; dispensed by Wells Pharmacy Network only after a clinician evaluation.
Also known as: FOXO4-D-Retro-Inverso peptide
How does FOXO4-DRI work?
FOXO4-DRI is studied for its ability to selectively disrupt the FOXO4–p53 complex inside senescent cells, releasing p53 to drive apoptosis of those cells while sparing healthy ones. In Baar et al.'s 2017 mouse work, it produced senolytic effects on aged tissues.
What is FOXO4-DRI studied for?
- Senolytic research - selective clearance of senescent cells
- Healthy-aging research interest
- Tissue-rejuvenation pre-clinical models
How is FOXO4-DRI taken?
Compounded as a subcutaneous injection in short, pulsed courses defined by your clinician. Not used continuously.
Is FOXO4-DRI FDA-approved? Is it safe?
Not FDA-approved for the prevention, treatment, or cure of any condition. Used inside research-informed, clinician-directed protocols only. Human clinical trial data is essentially absent. All clinical use is research-informed and considered experimental. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
The protocols below are dispensed by Wells Pharmacy Network and contain FOXO4-DRI. Each one is prescribed only after a clinician evaluation.
What does the research say about FOXO4-DRI?
The 2017 Baar et al. paper in Cell remains the foundational work. No published phase-1 human trials.
Citations & further reading
Considering FOXO4-DRI as part of a protocol?
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