KPV: How It Works, What It's Studied For & Safety
KPV is a small C-terminal tripeptide of α-melanocyte-stimulating hormone studied for anti-inflammatory signaling in gut, skin, and oral-mucosal research. Clinicians consider it for inflammatory bowel disease research (preclinical models). It is not FDA-approved as a finished drug product and is dispensed by Wells Pharmacy Network only after a licensed clinician evaluates intake, history, and labs.
Also known as: Lysine-Proline-Valine, α-MSH(11-13)
How does KPV work?
KPV is the lysine-proline-valine sequence at the C-terminus of α-MSH. Unlike full-length α-MSH it does not engage melanocortin pigmentation pathways meaningfully; instead it is studied for inhibition of NF-κB and pro-inflammatory cytokine signaling, with effects in epithelial and mucosal cells.
What is KPV studied for?
- Inflammatory bowel disease research (preclinical models)
- Topical skin and oral-mucosal inflammation research
- Adjunct in clinician-directed gut-repair and post-procedure protocols
How is KPV taken?
Compounded as oral capsules, sublingual troches, topical creams, or subcutaneous injections in clinician-directed protocols. Not FDA-approved.
Is KPV FDA-approved? Is it safe?
Not FDA-approved for the prevention, treatment, or cure of any condition. Used inside research-informed, clinician-directed protocols only. Reported research safety has been favorable; long-term human data is limited. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about KPV?
Preclinical models support anti-inflammatory effects in gut and skin epithelia; controlled human-outcome trials have not been published.
Citations & further reading
Considering KPV as part of a protocol?
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