PT-141: How It Works, What It's Studied For & Safety
PT-141 is a melanocortin-receptor agonist studied for central effects on sexual desire - distinct from PDE5 inhibitors that act on blood flow. Clinicians consider it for hypoactive sexual desire disorder in premenopausal women (FDA-approved as Vyleesi, subcutaneous injection). Not FDA-approved; dispensed by Wells Pharmacy Network only after a clinician evaluation.
Also known as: Bremelanotide, Vyleesi
How does PT-141 work?
PT-141 is a synthetic analog of α-MSH that activates the MC4 (and MC3) melanocortin receptors in CNS pathways involved in sexual arousal. Unlike sildenafil and tadalafil, it does not act on the vascular blood-flow axis.
What is PT-141 studied for?
- Hypoactive sexual desire disorder in premenopausal women (FDA-approved as Vyleesi, subcutaneous injection)
- Off-label male sexual-desire support in clinician-directed protocols
- Combination protocols layering central desire signaling with PDE5 vascular support
How is PT-141 taken?
FDA-approved subcutaneous auto-injector (Vyleesi). Compounded oral, troche, and nasal-spray preparations are dispensed for off-label clinician-directed protocols.
Is PT-141 FDA-approved? Is it safe?
Vyleesi is FDA-approved for HSDD in premenopausal women. Compounded variants are not FDA-approved. Cardiovascular history must be reviewed before starting any preparation. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about PT-141?
Phase-3 RECONNECT trials supported the Vyleesi approval. Off-label male and combination-protocol use is clinical-experience-driven.
Citations & further reading
Considering PT-141 as part of a protocol?
Browse Regen Therapy's catalog or start a clinician evaluation. Every prescription is reviewed by a licensed clinician and dispensed by Wells Pharmacy Network.
Browse the catalog →