SS-31: How It Works, What It's Studied For & Safety
SS-31 is a mitochondrial-targeted peptide that binds cardiolipin on the inner mitochondrial membrane, studied for cellular-energy and cardiovascular research. Clinicians consider it for heart failure with preserved ejection fraction (HFpEF) - phase-3 trial program (PROGRESS). Not FDA-approved; dispensed by Wells Pharmacy Network only after a clinician evaluation.
Also known as: Elamipretide, MTP-131, Bendavia
How does SS-31 work?
SS-31 (elamipretide) is a small, cell-permeable peptide that selectively localizes to the inner mitochondrial membrane and binds cardiolipin. By stabilizing cristae structure and supporting electron-transport-chain efficiency, it is studied for restoring mitochondrial bioenergetics in stressed or aged tissues.
What is SS-31 studied for?
- Heart failure with preserved ejection fraction (HFpEF) - phase-3 trial program (PROGRESS)
- Primary mitochondrial myopathy
- Age-related skeletal-muscle and cardiovascular endurance research
How is SS-31 taken?
Compounded as a subcutaneous injection in clinician-directed cycles. The branded clinical-trial preparation is administered as a daily subcutaneous injection.
Is SS-31 FDA-approved? Is it safe?
Not FDA-approved for the prevention, treatment, or cure of any condition. Used inside research-informed, clinician-directed protocols only. (Investigational under sponsor IND for specific mitochondrial indications.) Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
The protocols below are dispensed by Wells Pharmacy Network and contain SS-31. Each one is prescribed only after a clinician evaluation.
What does the research say about SS-31?
Multiple sponsor-led clinical trials in cardiac and mitochondrial-disease populations; results have been mixed and an FDA approval has not yet been issued.
Citations & further reading
Considering SS-31 as part of a protocol?
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