Tesofensine: How It Works, What It's Studied For & Safety
Tesofensine is an investigational triple monoamine reuptake inhibitor (serotonin, norepinephrine, dopamine) studied for chronic weight management; not FDA-approved. Clinicians consider it for chronic weight management in adults with obesity (Phase 2 and Phase 3 research outside the US). Not FDA-approved; dispensed by Wells Pharmacy Network only after a clinician evaluation.
Also known as: NS2330
How does Tesofensine work?
Tesofensine inhibits the reuptake of serotonin, norepinephrine, and dopamine in the central nervous system, increasing their availability in appetite-regulating circuits. The downstream effect is reduced food intake and a modest increase in resting energy expenditure.
What is Tesofensine studied for?
- Chronic weight management in adults with obesity (Phase 2 and Phase 3 research outside the US)
- Originally evaluated in Parkinson's disease and Alzheimer's disease (development discontinued for those indications)
How is Tesofensine taken?
Investigational once-daily oral capsules. Not FDA-approved. Compounded preparations on this site are not FDA-approved.
Is Tesofensine FDA-approved? Is it safe?
Not FDA-approved for the prevention, treatment, or cure of any condition. Used inside research-informed, clinician-directed protocols only. Reported effects in trials include increases in heart rate and blood pressure, dry mouth, insomnia, and constipation. Cardiovascular and psychiatric history must be reviewed before initiation. Compounded prescription-only preparations are dispensed by Wells Pharmacy Network. Eligibility is decided by a licensed clinician based on intake and labs, not by checkout. Compounded products on this site are not FDA-approved and are not generic equivalents of any branded medication.
In the Regen Therapy catalog
This compound does not currently appear in an active Regen Therapy protocol. Browse the full catalog for adjacent options.
What does the research say about Tesofensine?
Phase 2 obesity trials (TIPO-1) reported substantial weight reductions at 24 weeks. Subsequent Phase 3 development for obesity has been pursued primarily outside the US.
Citations & further reading
Considering Tesofensine as part of a protocol?
Browse Regen Therapy's catalog or start a clinician evaluation. Every prescription is reviewed by a licensed clinician and dispensed by Wells Pharmacy Network.
Browse the catalog →